TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Lauren Mccallister
Curated by ChEMBL
Lauren Mccallister
Curated by ChEMBL
Affinity DataIC50: 0.152nMAssay Description:Inhibition of human PCSK9 by Alexa Fluor 647 staining based TR-FRET assayMore data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Lauren Mccallister
Curated by ChEMBL
Lauren Mccallister
Curated by ChEMBL
Affinity DataIC50: 0.327nMAssay Description:Inhibition of human PCSK9 by Alexa Fluor 647 staining based TR-FRET assayMore data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Lauren Mccallister
Curated by ChEMBL
Lauren Mccallister
Curated by ChEMBL
Affinity DataIC50: 0.438nMAssay Description:Inhibition of human PCSK9 by Alexa Fluor 647 staining based TR-FRET assayMore data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Lauren Mccallister
Curated by ChEMBL
Lauren Mccallister
Curated by ChEMBL
Affinity DataIC50: 0.570nMAssay Description:Inhibition of human PCSK9 by Alexa Fluor 647 staining based TR-FRET assayMore data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Lauren Mccallister
Curated by ChEMBL
Lauren Mccallister
Curated by ChEMBL
Affinity DataIC50: 0.850nMAssay Description:Inhibition of human PCSK9 by Alexa Fluor 647 staining based TR-FRET assayMore data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Lauren Mccallister
Curated by ChEMBL
Lauren Mccallister
Curated by ChEMBL
Affinity DataIC50: 0.930nMAssay Description:Inhibition of human PCSK9 by Alexa Fluor 647 staining based TR-FRET assayMore data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Lauren Mccallister
Curated by ChEMBL
Lauren Mccallister
Curated by ChEMBL
Ligand Info
In DepthDetails
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Lauren Mccallister
Curated by ChEMBL
Lauren Mccallister
Curated by ChEMBL
Ligand Info
In DepthDetails
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Lauren Mccallister
Curated by ChEMBL
Lauren Mccallister
Curated by ChEMBL
Ligand Info
In DepthDetails
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Lauren Mccallister
Curated by ChEMBL
Lauren Mccallister
Curated by ChEMBL
Affinity DataIC50: 202nMAssay Description:Inhibition of human PCSK9 in HepG2 cells incubated for 24 hrs followed by medium replenishment and measured after 24 hrs by ELISAMore data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Lauren Mccallister
Curated by ChEMBL
Lauren Mccallister
Curated by ChEMBL
Ligand Info
In DepthDetails
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Lauren Mccallister
Curated by ChEMBL
Lauren Mccallister
Curated by ChEMBL
Affinity DataIC50: 250nMAssay Description:Inhibition of human PCSK9 in HepG2 cells incubated for 48 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Lauren Mccallister
Curated by ChEMBL
Lauren Mccallister
Curated by ChEMBL
Affinity DataIC50: 300nMAssay Description:Inhibition of human PCSK9 in HepG2 cells incubated for 48 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Lauren Mccallister
Curated by ChEMBL
Lauren Mccallister
Curated by ChEMBL
In DepthDetails
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Lauren Mccallister
Curated by ChEMBL
Lauren Mccallister
Curated by ChEMBL
Ligand Info
In DepthDetails
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Lauren Mccallister
Curated by ChEMBL
Lauren Mccallister
Curated by ChEMBL
Affinity DataIC50: 424nMAssay Description:Inhibition of human PCSK9More data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Lauren Mccallister
Curated by ChEMBL
Lauren Mccallister
Curated by ChEMBL
Affinity DataIC50: 440nMAssay Description:In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...More data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Lauren Mccallister
Curated by ChEMBL
Lauren Mccallister
Curated by ChEMBL
Affinity DataIC50: 500nMAssay Description:Inhibition of His-tagged PCSK9 (unknown origin) binding to recombinant LDLR-AB domain (unknown origin) by ELISAMore data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Lauren Mccallister
Curated by ChEMBL
Lauren Mccallister
Curated by ChEMBL
Affinity DataIC50: 520nMAssay Description:In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...More data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Lauren Mccallister
Curated by ChEMBL
Lauren Mccallister
Curated by ChEMBL
Affinity DataIC50: 592nMAssay Description:In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...More data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Lauren Mccallister
Curated by ChEMBL
Lauren Mccallister
Curated by ChEMBL
Ligand Info
In DepthDetails
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Lauren Mccallister
Curated by ChEMBL
Lauren Mccallister
Curated by ChEMBL
Affinity DataIC50: 640nMAssay Description:In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...More data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Lauren Mccallister
Curated by ChEMBL
Lauren Mccallister
Curated by ChEMBL
Affinity DataIC50: 690nMAssay Description:In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...More data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Lauren Mccallister
Curated by ChEMBL
Lauren Mccallister
Curated by ChEMBL
Ligand Info
In DepthDetails
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Lauren Mccallister
Curated by ChEMBL
Lauren Mccallister
Curated by ChEMBL
Ligand Info
In DepthDetails
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Lauren Mccallister
Curated by ChEMBL
Lauren Mccallister
Curated by ChEMBL
Affinity DataIC50: 750nMAssay Description:Inhibition of PCSK9 translation in human THP-1 cells by AlphaLISA assayMore data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Lauren Mccallister
Curated by ChEMBL
Lauren Mccallister
Curated by ChEMBL
Affinity DataIC50: 760nMAssay Description:For the peptide affinity determinations, biotinylated PCSK9 was immobilized to NeutrAvidin-coated MaxiSorp Immuno-Plates and incubated with a mixture...More data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Lauren Mccallister
Curated by ChEMBL
Lauren Mccallister
Curated by ChEMBL
Affinity DataIC50: 780nMAssay Description:Inhibition of PCSK9 translation in human THP-1 cells by AlphaLISA assayMore data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Lauren Mccallister
Curated by ChEMBL
Lauren Mccallister
Curated by ChEMBL
Affinity DataIC50: 800nMAssay Description:In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...More data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Lauren Mccallister
Curated by ChEMBL
Lauren Mccallister
Curated by ChEMBL
Affinity DataIC50: 800nMAssay Description:An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...More data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Lauren Mccallister
Curated by ChEMBL
Lauren Mccallister
Curated by ChEMBL
Affinity DataIC50: 800nMAssay Description:An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...More data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Lauren Mccallister
Curated by ChEMBL
Lauren Mccallister
Curated by ChEMBL
In DepthDetails
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Lauren Mccallister
Curated by ChEMBL
Lauren Mccallister
Curated by ChEMBL
Affinity DataIC50: 900nMAssay Description:Inhibition of human PCSK9 in HepG2 cells incubated for 48 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Lauren Mccallister
Curated by ChEMBL
Lauren Mccallister
Curated by ChEMBL
Affinity DataIC50: 900nMAssay Description:Inhibition of PCSK9 translation in human THP-1 cells by AlphaLISA assayMore data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Lauren Mccallister
Curated by ChEMBL
Lauren Mccallister
Curated by ChEMBL
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human PCSK9 in HepG2 cells incubated for 48 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Lauren Mccallister
Curated by ChEMBL
Lauren Mccallister
Curated by ChEMBL
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of tEGF-A[HA] binding to biotinylated human PCSK9 incubated for 2 hrs by ELISA based competitive binding assayMore data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Lauren Mccallister
Curated by ChEMBL
Lauren Mccallister
Curated by ChEMBL
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of PCSK9 translation in human THP-1 cells by AlphaLISA assayMore data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Lauren Mccallister
Curated by ChEMBL
Lauren Mccallister
Curated by ChEMBL
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human PCSK9 in HepG2 cells incubated for 48 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Lauren Mccallister
Curated by ChEMBL
Lauren Mccallister
Curated by ChEMBL
Affinity DataIC50: 1.40E+3nMAssay Description:For the peptide affinity determinations, biotinylated PCSK9 was immobilized to NeutrAvidin-coated MaxiSorp Immuno-Plates and incubated with a mixture...More data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Lauren Mccallister
Curated by ChEMBL
Lauren Mccallister
Curated by ChEMBL
Affinity DataIC50: 1.50E+3nMAssay Description:An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...More data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Lauren Mccallister
Curated by ChEMBL
Lauren Mccallister
Curated by ChEMBL
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of human PCSK9 in HepG2 cells incubated for 48 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Lauren Mccallister
Curated by ChEMBL
Lauren Mccallister
Curated by ChEMBL
Affinity DataIC50: 1.50E+3nMAssay Description:An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...More data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Lauren Mccallister
Curated by ChEMBL
Lauren Mccallister
Curated by ChEMBL
Affinity DataIC50: 1.50E+3nMAssay Description:An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...More data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Lauren Mccallister
Curated by ChEMBL
Lauren Mccallister
Curated by ChEMBL
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of human PCSK9More data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Lauren Mccallister
Curated by ChEMBL
Lauren Mccallister
Curated by ChEMBL
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of PCSK9 binding to LDLR in human HuH7 cells after 5 hrs by On-cell Western assayMore data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Lauren Mccallister
Curated by ChEMBL
Lauren Mccallister
Curated by ChEMBL
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of PCSK9 translation in human THP-1 cells by AlphaLISA assayMore data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Lauren Mccallister
Curated by ChEMBL
Lauren Mccallister
Curated by ChEMBL
Affinity DataIC50: 1.70E+3nMAssay Description:In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...More data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Lauren Mccallister
Curated by ChEMBL
Lauren Mccallister
Curated by ChEMBL
Affinity DataIC50: 1.70E+3nMAssay Description:An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...More data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Lauren Mccallister
Curated by ChEMBL
Lauren Mccallister
Curated by ChEMBL
Affinity DataIC50: 1.70E+3nMAssay Description:In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...More data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Lauren Mccallister
Curated by ChEMBL
Lauren Mccallister
Curated by ChEMBL
Affinity DataIC50: 1.80E+3nMAssay Description:An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...More data for this Ligand-Target Pair